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Clinical efficacy of Chaipu Decoction combined with Seretide in the treatment of bronchial asthma and its impact on TNF-α and CD4+/CD8+

发布时间：2026-03-13点击次数：

  • DOI码：10.1038/s41598-026-37033-9
  • 发表刊物：Scientific Reports
  • 摘要：This single-center randomized controlled trial evaluated whether Chaipu Decoction used as an adjunct to Seretide improves clinical and immunological outcomes in patients with bronchial asthma. A total of 300 adults treated between January 2023 and January 2025 were randomly assigned to receive either Chaipu Decoction plus Seretide or Seretide alone for 12 weeks. Clinical efficacy, adverse reactions, Traditional Chinese Medicine (TCM) syndrome scores, pulmonary function indices (FEV1, FVC, FEV1/FVC and PEF), serum TNF-α, peripheral blood CD4+/CD8 + ratio, and Asthma Control Test (ACT) scores were assessed. The study was approved by the Ethics Committee of the Affiliated Hospital of Shandong University of Traditional Chinese Medicine (Approval No. SDTCM-EA2023-002), and written informed consent was obtained from all participants. Patients receiving the combined treatment achieved a higher total effective rate than those receiving Seretide alone (86.7% vs. 66.7%, p < 0.05), without a significant increase in adverse reactions. Compared with the control group, the combination group showed greater reductions in TCM syndrome scores, larger improvements in lung function, a more pronounced decrease in TNF-α, and a greater increase in the CD4+/CD8+ ratio after treatment, together with superior improvement in ACT scores. These findings indicate that Chaipu Decoction combined with Seretide can provide additional clinical and immunological benefit in bronchial asthma over a 12-week treatment period while maintaining acceptable short-term tolerability.
  • 论文类型：期刊论文
  • 卷号：16
  • 页面范围：13449
  • 是否译文：否
  • 发表时间：2026-03-13
  • 收录刊物：SCI、EI

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李远哲

职务：Professor
主要任职：

个人信息

  • 博士生导师
    硕士生导师
  • 教师英文名称：Yuanzhe
  • 教师拼音名称：liyuanzhe
  • 所在单位：碳中和研究院
  • 职务：Professor
  • 学历：博士研究生毕业
  • 办公地点：中国矿业大学(文昌校区) 教三楼 碳中和研究院
  • 性别：男
  • 联系方式：yuanzhe.li@cumt.edu.cn
  • 学位：哲学博士学位
  • 毕业院校：Nanyang Technological University

学术荣誉：

  • 2025当选：江苏特聘教授

曾获荣誉：

  • 2023-12-27新加坡国家级范畴三（CSE3）半导体行业专家 & 碳税 主任审核员
  • 2023-12-27新加坡经管局资源效率补助（REG(E)）减碳项目 主任验证审核员
  • 2025-11-11净零路径 (NetZero Pathway) 主任验证审核员
  • 2025-02-28Verra 碳排放信用 VCS 主任审核员
  • 2024-12-02碳中和 ISO14068认证 主任审核员
  • 2024-11-27可持续性保证（ACSAP）认证资格 (AA1000注册)
  • 2025-09-01ISO14067 产品碳认证 外部主任审核员
  • 2024-03-04ISO14064 温室气体排放与碳核查 外部主任审核员（ANAB注册验证）
  • 2025-10-01ISO50001 能源管理体系外部主任审员
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  • 2024-04-01ISO14001 环境管理体系 外部主任审核员 (CQI & IRCA注册)
  • 2017-09-18新加坡人力部注册安全官（WSHO）
  • 2025-09-01江苏特聘教授

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