影响因子：8.307
DOI码：10.1039/c9nr09577b
发表刊物：Nanoscale (IF: 8.307, JCR 1区Top期刊)
摘要：Recently, phosphorene, a novel two-dimensional nanomaterial with a puckered surface morphology, was shown to exhibit cytotoxicity, but its underlying molecular mechanisms remain unknown. Herein, using large scale molecular dynamics simulations, we show that phosphorene nanosheets can penetrate into and extract large amounts of phospholipids from the cell membranes due to the strong dispersion interaction between phosphorene and lipid molecules, which would reduce cell viability. The extracted phospholipid molecules are aligned along the wrinkle direction of the phosphorene nanosheet because of its unique puckered structure. Our results also reveal that small phosphorene nanosheets penetrate into the cell membrane in a specific direction which is determined by the size and surface topography of phosphorene and the thickness of the membrane. These findings might shed light on understanding phosphorene's cytotoxicity and would be helpful for the future potential biomedical applications of phosphorene, such as biosensors and antibacterial agents.
第一作者：Wei Zhang*
合写作者：Yezhe Chen,Tien Huynh,Yunqiu Yang,Xianqing Yang,Ruhong Zhou*
论文类型：期刊论文
卷号：12
期号：4
页面范围：2810-2819
是否译文：否
发表时间：2020-01-28
收录刊物：SCI
发布期刊链接：https://pubs.rsc.org/en/content/articlelanding/2020/nr/c9nr09577b#!divAbstract