Impact Factor:3.466
DOI number:10.1021/acs.jpcb.0c07476
Affiliation of Author(s):China University of Mining and Technology
Journal:Journal of Physical Chemistry B
Abstract:Phosphorene is a novel two-dimensional nanomaterial with a puckered surface morphology, which has broad potential application prospects in the fields of biology and medicine. Phosphorene nanosheets are easily oxidized and form phosphorene oxide (PO) in an aerobic environment, whose biological effect remains unknown. In this paper, using large-scale molecular dynamics simulations, we show that the PO nanosheets can penetrate into and destructively extract large amounts of phospholipids from the lipid membrane. The PO nanosheets with a higher oxidation concentration have less extraction of phospholipids, while its oxidation mode has no effect on the extraction of phospholipids. Moreover, inserting PO nanosheets into the lipid membrane can enhance the diffusion of phospholipids on the membrane. These findings can shed light on understanding/designing the membrane–nanomaterial interactions.
First Author:Yezhe Chen
Co-author:Wei Zhang*,Chuanfu Huang,Mei Feng,Yunqiu Yang,Yuanyuan Gou
Indexed by:Journal paper
Volume:125
Issue:10
Page Number:2636–2643
Translation or Not:no
Date of Publication:2021-01-25
Included Journals:SCI
Links to published journals:https://pubs.acs.org/doi/10.1021/acs.jpcb.0c07476
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